Potassium DCA

Sodium DCA ✓ Larger research base ✓ Better characterised Contains sodium MW: 150.92 Potassium DCA ✓ Sodium-free ✓ Same mechanism Rarer to source MW: 172.97 VS

Potassium DCA vs Sodium DCA — What’s the Actual Difference?

Same active anion, different counterion — and why that matters for some researchers.

Sodium DCA and potassium DCA deliver the same active molecule — the dichloroacetate anion. Once dissolved in water or biological fluids, both salts dissociate completely. The sodium or potassium counterion does not enter cells; it is the dichloroacetate anion that crosses membranes and inhibits PDK.

The practical differences are real but limited. Sodium DCA has an enormous research advantage — virtually all published human and animal studies use the sodium salt. This means dosing protocols, side effect profiles, and pharmacokinetic data are far better established for sodium DCA.

Molecular weight differs: sodium DCA is 150.92 g/mol; potassium DCA is 172.97 g/mol. To deliver a molar-equivalent dose of the dichloroacetate anion, you need approximately 14.7% more mass of KDCA than sodium DCA. For example, 1000mg of sodium DCA is equivalent to approximately 1147mg of potassium DCA.

Who might prefer KDCA? Individuals on restricted sodium diets for cardiovascular or renal reasons. Those following specific research protocols that specify the potassium form. Anyone who tolerates potassium better than sodium for individual physiological reasons.

Both forms require the same quality standards: HPLC purity, MCA testing, independent COA, and heavy metals panel.

This article is for informational and educational purposes only. AuraDCA products are intended for research use only.